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The components of the matrix secreted by fibroblasts can directly interact with membrane receptors, like integrins and syndecans, and initiate intracellular signalling pathways which play important roles in various processes like organ morphogenesis, cell migration or mechanotransduction ( Fibroblasts are involved not only in the deposition of ECM components, but also in their appropriate remodelling through crosslinking and proteolysis
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doi: 10.1139/jpn.0402 236 LiebenCKBloklandAWesterinkBDeutzNE
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